Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study

INTRODUCTION: The incidence of acute coronary syndrome is rising in step with the growth of life expectancy. An increase in the age of patients with coronary artery disease has been related to in-hospital mortality, which has seen an upsurge over a short period of time. However, there is no consensu...

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Autores principales: Carmona-Segovia, Ada del Mar, Doncel-Abad, María Victoria, Becerra-Muñoz, Víctor M, Rodríguez-Capitán, Jorge, Sabatel-Pérez, Fernando, Flores-López, María, Sánchez-Quintero, María José, Medina-Vera, Dina, Molina-Ramos, Ana Isabel, El Bekay, Rajaa, Morales-Asencio, José Miguel, Angullo-Gómez, María, García-Rodríguez, Luis, Palma-Martí, Lucía, Pavón-Morón, Francisco Javier, Jiménez-Navarro, Manuel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886411/
https://www.ncbi.nlm.nih.gov/pubmed/35228293
http://dx.doi.org/10.1136/bmjopen-2021-058042
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author Carmona-Segovia, Ada del Mar
Doncel-Abad, María Victoria
Becerra-Muñoz, Víctor M
Rodríguez-Capitán, Jorge
Sabatel-Pérez, Fernando
Flores-López, María
Sánchez-Quintero, María José
Medina-Vera, Dina
Molina-Ramos, Ana Isabel
El Bekay, Rajaa
Morales-Asencio, José Miguel
Angullo-Gómez, María
García-Rodríguez, Luis
Palma-Martí, Lucía
Pavón-Morón, Francisco Javier
Jiménez-Navarro, Manuel F.
author_facet Carmona-Segovia, Ada del Mar
Doncel-Abad, María Victoria
Becerra-Muñoz, Víctor M
Rodríguez-Capitán, Jorge
Sabatel-Pérez, Fernando
Flores-López, María
Sánchez-Quintero, María José
Medina-Vera, Dina
Molina-Ramos, Ana Isabel
El Bekay, Rajaa
Morales-Asencio, José Miguel
Angullo-Gómez, María
García-Rodríguez, Luis
Palma-Martí, Lucía
Pavón-Morón, Francisco Javier
Jiménez-Navarro, Manuel F.
author_sort Carmona-Segovia, Ada del Mar
collection PubMed
description INTRODUCTION: The incidence of acute coronary syndrome is rising in step with the growth of life expectancy. An increase in the age of patients with coronary artery disease has been related to in-hospital mortality, which has seen an upsurge over a short period of time. However, there is no consensus about the percutaneous coronary angioplasty strategy to follow for older patients with multivessel coronary artery disease (MVCAD). Complete revascularisation (CR) or incomplete revascularisation (ICR) strategy depends on prognosis but this has not yet been accurately described because of geriatric conditions and comorbidities. The aim of this study is to evaluate changes of clinical and biochemical parameters in older patients with MVCAD undergoing revascularisation and to establish a prognostic stratification model for CR and ICR. METHODS AND ANALYSIS: This observational, longitudinal, prospective study will include 150 patients with MVCAD and subsequent revascularisation who attend the Hospital Universitario Virgen de la Victoria (Málaga, Spain). Because of the dropout rates, 180 patients will be recruited at the beginning. Sociodemographic characteristics, clinical and angiographic parameters, and biochemical variables, such as cardiovascular, metabolic, inflammatory, stress oxidative biomarkers, will be collected in the admission for coronary revascularisation and three follow-ups at 6, 12 and 18 months. Statistical analyses will be conducted with these data using CR and ICR as the primary exposure variable. Relevant explanatory variables will be selected from a predictive model for their inclusion in a prognostic stratification model. The primary outcome measures will be major adverse cardiovascular events. ETHICS AND DISSEMINATION: Protocols and patient information have been approved by the regional research ethics committee (CEIm Provincial de Málaga-PEIBA (PI0131/2020). The results will be disseminated in international peer-reviewed journals, presented at conferences in Cardiology and Gerontology, and sent to participants, medical and health service managers, clinicians and other researchers.
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spelling pubmed-88864112022-03-17 Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study Carmona-Segovia, Ada del Mar Doncel-Abad, María Victoria Becerra-Muñoz, Víctor M Rodríguez-Capitán, Jorge Sabatel-Pérez, Fernando Flores-López, María Sánchez-Quintero, María José Medina-Vera, Dina Molina-Ramos, Ana Isabel El Bekay, Rajaa Morales-Asencio, José Miguel Angullo-Gómez, María García-Rodríguez, Luis Palma-Martí, Lucía Pavón-Morón, Francisco Javier Jiménez-Navarro, Manuel F. BMJ Open Cardiovascular Medicine INTRODUCTION: The incidence of acute coronary syndrome is rising in step with the growth of life expectancy. An increase in the age of patients with coronary artery disease has been related to in-hospital mortality, which has seen an upsurge over a short period of time. However, there is no consensus about the percutaneous coronary angioplasty strategy to follow for older patients with multivessel coronary artery disease (MVCAD). Complete revascularisation (CR) or incomplete revascularisation (ICR) strategy depends on prognosis but this has not yet been accurately described because of geriatric conditions and comorbidities. The aim of this study is to evaluate changes of clinical and biochemical parameters in older patients with MVCAD undergoing revascularisation and to establish a prognostic stratification model for CR and ICR. METHODS AND ANALYSIS: This observational, longitudinal, prospective study will include 150 patients with MVCAD and subsequent revascularisation who attend the Hospital Universitario Virgen de la Victoria (Málaga, Spain). Because of the dropout rates, 180 patients will be recruited at the beginning. Sociodemographic characteristics, clinical and angiographic parameters, and biochemical variables, such as cardiovascular, metabolic, inflammatory, stress oxidative biomarkers, will be collected in the admission for coronary revascularisation and three follow-ups at 6, 12 and 18 months. Statistical analyses will be conducted with these data using CR and ICR as the primary exposure variable. Relevant explanatory variables will be selected from a predictive model for their inclusion in a prognostic stratification model. The primary outcome measures will be major adverse cardiovascular events. ETHICS AND DISSEMINATION: Protocols and patient information have been approved by the regional research ethics committee (CEIm Provincial de Málaga-PEIBA (PI0131/2020). The results will be disseminated in international peer-reviewed journals, presented at conferences in Cardiology and Gerontology, and sent to participants, medical and health service managers, clinicians and other researchers. BMJ Publishing Group 2022-02-28 /pmc/articles/PMC8886411/ /pubmed/35228293 http://dx.doi.org/10.1136/bmjopen-2021-058042 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Cardiovascular Medicine
Carmona-Segovia, Ada del Mar
Doncel-Abad, María Victoria
Becerra-Muñoz, Víctor M
Rodríguez-Capitán, Jorge
Sabatel-Pérez, Fernando
Flores-López, María
Sánchez-Quintero, María José
Medina-Vera, Dina
Molina-Ramos, Ana Isabel
El Bekay, Rajaa
Morales-Asencio, José Miguel
Angullo-Gómez, María
García-Rodríguez, Luis
Palma-Martí, Lucía
Pavón-Morón, Francisco Javier
Jiménez-Navarro, Manuel F.
Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
title Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
title_full Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
title_fullStr Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
title_full_unstemmed Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
title_short Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
title_sort prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886411/
https://www.ncbi.nlm.nih.gov/pubmed/35228293
http://dx.doi.org/10.1136/bmjopen-2021-058042
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