LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

Lysosomes function not only as degradatory compartments but also as dynamic intracellular calcium ion stores. The transient receptor potential mucolipin 1 (TRPML1) channel mediates lysosomal Ca(2+) release, thereby participating in multiple cellular functions. The pentameric Ragulator complex, which...

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Detalles Bibliográficos
Autores principales: Sun, Jiandong, Liu, Yan, Hao, Xiaoning, Lin, Weiju, Su, Wenyue, Chiang, Emerald, Baudry, Michel, Bi, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886530/
https://www.ncbi.nlm.nih.gov/pubmed/35099830
http://dx.doi.org/10.15252/embj.2021108119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886530/
https://www.ncbi.nlm.nih.gov/pubmed/35099830
http://dx.doi.org/10.15252/embj.2021108119

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