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SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation

The initiation of Okazaki fragment synthesis during cellular DNA replication is a crucial step for lagging strand synthesis, which is carried out by the primase function of DNA polymerase α‐primase (Pol‐prim). Since cellular replication protein A (RPA) prevents primase from starting RNA synthesis on...

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Detalles Bibliográficos
Autores principales: Onwubiko, Nichodemus O., Scheffel, Felicia, Tessmer, Ingrid, Nasheuer, Heinz Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886539/
https://www.ncbi.nlm.nih.gov/pubmed/35073603
http://dx.doi.org/10.1002/2211-5463.13373