Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease

Iron dysregulation, dopamine depletion, cellular oxidative stress and α-synuclein protein mis-folding are key neuronal pathological features seen in the progression of Parkinson's disease. Iron chelators endowed with one or more therapeutic modes of action have long been suggested as disease mo...

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Detalles Bibliográficos
Autores principales: Lewis, Frank W., Bird, Kathleen, Navarro, Jean-Philippe, El Fallah, Rawa, Brandel, Jeremy, Hubscher-Bruder, Véronique, Tsatsanis, Andrew, Duce, James A., Tétard, David, Bourne, Samuel, Maina, Mahmoud, Pienaar, Ilse S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886574/
https://www.ncbi.nlm.nih.gov/pubmed/35147617
http://dx.doi.org/10.1039/d1dt02604f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886574/
https://www.ncbi.nlm.nih.gov/pubmed/35147617
http://dx.doi.org/10.1039/d1dt02604f

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