RNase H is an exo- and endoribonuclease with asymmetric directionality, depending on the binding mode to the structural variants of RNA:DNA hybrids

RNase H is involved in fundamental cellular processes and is responsible for removing the short stretch of RNA from Okazaki fragments and the long stretch of RNA from R-loops. Defects in RNase H lead to embryo lethality in mice and Aicardi-Goutieres syndrome in humans, suggesting the importance of R...

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Detalles Bibliográficos
Autores principales: Lee, Hyunjee, Cho, HyeokJin, Kim, Jooyoung, Lee, Sua, Yoo, Jungmin, Park, Daeho, Lee, Gwangrog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886854/
https://www.ncbi.nlm.nih.gov/pubmed/34788459
http://dx.doi.org/10.1093/nar/gkab1064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886854/
https://www.ncbi.nlm.nih.gov/pubmed/34788459
http://dx.doi.org/10.1093/nar/gkab1064

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