ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterised by the loss of upper and lower motor neurons. Increasing evidence indicates that neuroinflammation mediated by microglia contributes to ALS pathogenesis. This microglial activation is evident...

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Detalles Bibliográficos
Autores principales: Quek, Hazel, Cuní-López, Carla, Stewart, Romal, Colletti, Tiziana, Notaro, Antonietta, Nguyen, Tam Hong, Sun, Yifan, Guo, Christine C., Lupton, Michelle K., Roberts, Tara L., Lim, Yi Chieh, Oikari, Lotta E., La Bella, Vincenzo, White, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887023/
https://www.ncbi.nlm.nih.gov/pubmed/35227277
http://dx.doi.org/10.1186/s12974-022-02421-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887023/
https://www.ncbi.nlm.nih.gov/pubmed/35227277
http://dx.doi.org/10.1186/s12974-022-02421-1

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