YTHDC2 control of gametogenesis requires helicase activity but not m(6)A binding

Mechanisms regulating meiotic progression in mammals are poorly understood. The N(6)-methyladenosine (m(6)A) reader and 3′ → 5′ RNA helicase YTHDC2 switches cells from mitotic to meiotic gene expression programs and is essential for meiotic entry, but how this critical cell fate change is accomplish...

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Detalles Bibliográficos
Autores principales: Saito, Yuhki, Hawley, Ben R., Puno, M. Rhyan, Sarathy, Shreya N., Lima, Christopher D., Jaffrey, Samie R., Darnell, Robert B., Keeney, Scott, Jain, Devanshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887132/
https://www.ncbi.nlm.nih.gov/pubmed/35058317
http://dx.doi.org/10.1101/gad.349190.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887132/
https://www.ncbi.nlm.nih.gov/pubmed/35058317
http://dx.doi.org/10.1101/gad.349190.121

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