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YTHDC2 control of gametogenesis requires helicase activity but not m(6)A binding
Mechanisms regulating meiotic progression in mammals are poorly understood. The N(6)-methyladenosine (m(6)A) reader and 3′ → 5′ RNA helicase YTHDC2 switches cells from mitotic to meiotic gene expression programs and is essential for meiotic entry, but how this critical cell fate change is accomplish...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887132/ https://www.ncbi.nlm.nih.gov/pubmed/35058317 http://dx.doi.org/10.1101/gad.349190.121 |