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The inner workings of replisome-dependent control of DNA damage tolerance

Genomic DNA is continuously challenged by endogenous and exogenous sources of damage. The resulting lesions may act as physical blocks to DNA replication, necessitating repair mechanisms to be intrinsically coupled to the DNA replisome machinery. DNA damage tolerance (DDT) is comprised of translesio...

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Detalles Bibliográficos
Autores principales: Zhang, Tianpeng, Greenberg, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887134/
https://www.ncbi.nlm.nih.gov/pubmed/35193944
http://dx.doi.org/10.1101/gad.349408.122