Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes

Mouse models have been engineered to reveal the biological mechanisms of human diseases based on an assumption. The assumption is that orthologous genes underlie conserved phenotypes across species. However, genetically modified mouse orthologs of human genes do not often recapitulate human disease...

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Detalles Bibliográficos
Autores principales: Ha, Doyeon, Kim, Donghyo, Kim, Inhae, Oh, Youngchul, Kong, JungHo, Han, Seong Kyu, Kim, Sanguk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887464/
https://www.ncbi.nlm.nih.gov/pubmed/35137181
http://dx.doi.org/10.1093/nar/gkac050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887464/
https://www.ncbi.nlm.nih.gov/pubmed/35137181
http://dx.doi.org/10.1093/nar/gkac050

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