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Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes
Mouse models have been engineered to reveal the biological mechanisms of human diseases based on an assumption. The assumption is that orthologous genes underlie conserved phenotypes across species. However, genetically modified mouse orthologs of human genes do not often recapitulate human disease...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887464/ https://www.ncbi.nlm.nih.gov/pubmed/35137181 http://dx.doi.org/10.1093/nar/gkac050 |