Mechanistic decoupling of exonuclease III multifunctionality into AP endonuclease and exonuclease activities at the single-residue level

Bacterial exonuclease III (ExoIII) is a multifunctional enzyme that uses a single active site to perform two conspicuous activities: (i) apurinic/apyrimidinic (AP)-endonuclease and (ii) 3′→5′ exonuclease activities. The AP endonuclease activity results in AP site incision, while the exonuclease acti...

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Detalles Bibliográficos
Autores principales: Lee, Donghun, Oh, Sanghoon, Cho, HyeokJin, Yoo, Jungmin, Lee, Gwangrog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887469/
https://www.ncbi.nlm.nih.gov/pubmed/35137198
http://dx.doi.org/10.1093/nar/gkac043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887469/
https://www.ncbi.nlm.nih.gov/pubmed/35137198
http://dx.doi.org/10.1093/nar/gkac043

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