POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes

Trypanosoma brucei causes human African trypanosomiasis and sequentially expresses distinct VSGs, its major surface antigen, to achieve host immune evasion. VSGs are monoallelically expressed from subtelomeric loci, and telomere proteins regulate VSG monoallelic expression and VSG switching. T. bruc...

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Detalles Bibliográficos
Autores principales: Rabbani, M A G, Tonini, Maiko Luis, Afrin, Marjia, Li, Bibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887473/
https://www.ncbi.nlm.nih.gov/pubmed/35061898
http://dx.doi.org/10.1093/nar/gkac023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887473/
https://www.ncbi.nlm.nih.gov/pubmed/35061898
http://dx.doi.org/10.1093/nar/gkac023

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