The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging

The shelterin protein complex is required for telomere protection in various eukaryotic organisms. In mammals, the shelterin subunit TRF2 is specialized in preventing ATM activation at telomeres and chromosome end fusion in somatic cells. Here, we demonstrate that the zebrafish ortholog of TRF2 (enc...

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Detalles Bibliográficos
Autores principales: Ying, Yilin, Hu, Xuefei, Han, Peng, Mendez-Bermudez, Aaron, Bauwens, Serge, Eid, Rita, Tan, Li, Pousse, Mélanie, Giraud-Panis, Marie-Joseph, Lu, Yiming, Gilson, Eric, Ye, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887477/
https://www.ncbi.nlm.nih.gov/pubmed/35150283
http://dx.doi.org/10.1093/nar/gkac065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887477/
https://www.ncbi.nlm.nih.gov/pubmed/35150283
http://dx.doi.org/10.1093/nar/gkac065

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