Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs

N (6)-Threonylcarbamoyladenosine (t(6)A) is a universal and pivotal tRNA modification. KEOPS in eukaryotes participates in its biogenesis, whose mutations are connected with Galloway-Mowat syndrome. However, the tRNA substrate selection mechanism by KEOPS and t(6)A modification function in mammalian...

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Detalles Bibliográficos
Autores principales: Wang, Jin-Tao, Zhou, Jing-Bo, Mao, Xue-Ling, Zhou, Li, Chen, Meirong, Zhang, Wenhua, Wang, En-Duo, Zhou, Xiao-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887486/
https://www.ncbi.nlm.nih.gov/pubmed/35104889
http://dx.doi.org/10.1093/nar/gkac056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887486/
https://www.ncbi.nlm.nih.gov/pubmed/35104889
http://dx.doi.org/10.1093/nar/gkac056

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