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Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs
N (6)-Threonylcarbamoyladenosine (t(6)A) is a universal and pivotal tRNA modification. KEOPS in eukaryotes participates in its biogenesis, whose mutations are connected with Galloway-Mowat syndrome. However, the tRNA substrate selection mechanism by KEOPS and t(6)A modification function in mammalian...
Autores principales: | Wang, Jin-Tao, Zhou, Jing-Bo, Mao, Xue-Ling, Zhou, Li, Chen, Meirong, Zhang, Wenhua, Wang, En-Duo, Zhou, Xiao-Long |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887486/ https://www.ncbi.nlm.nih.gov/pubmed/35104889 http://dx.doi.org/10.1093/nar/gkac056 |
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