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Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism

There is an unmet clinical need for curative therapies to treat neurodegenerative disorders. Most mainstay treatments currently on the market only alleviate specific symptoms and do not reverse disease progression. The Pituitary adenylate cyclase-activating polypeptide (PACAP), an endogenous neurope...

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Detalles Bibliográficos
Autores principales: Apostol, Christopher R., Bernard, Kelsey, Tanguturi, Parthasaradhireddy, Molnar, Gabriella, Bartlett, Mitchell J., Szabò, Lajos, Liu, Chenxi, Ortiz, J. Bryce, Saber, Maha, Giordano, Katherine R., Green, Tabitha R. F., Melvin, James, Morrison, Helena W., Madhavan, Lalitha, Rowe, Rachel K., Streicher, John M., Heien, Michael L., Falk, Torsten, Polt, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887546/
https://www.ncbi.nlm.nih.gov/pubmed/35237767
http://dx.doi.org/10.3389/fddsv.2021.818003