Cargando…

Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism

There is an unmet clinical need for curative therapies to treat neurodegenerative disorders. Most mainstay treatments currently on the market only alleviate specific symptoms and do not reverse disease progression. The Pituitary adenylate cyclase-activating polypeptide (PACAP), an endogenous neurope...

Descripción completa

Detalles Bibliográficos
Autores principales:	Apostol, Christopher R., Bernard, Kelsey, Tanguturi, Parthasaradhireddy, Molnar, Gabriella, Bartlett, Mitchell J., Szabò, Lajos, Liu, Chenxi, Ortiz, J. Bryce, Saber, Maha, Giordano, Katherine R., Green, Tabitha R. F., Melvin, James, Morrison, Helena W., Madhavan, Lalitha, Rowe, Rachel K., Streicher, John M., Heien, Michael L., Falk, Torsten, Polt, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887546/ https://www.ncbi.nlm.nih.gov/pubmed/35237767 http://dx.doi.org/10.3389/fddsv.2021.818003

Ejemplares similares

Synthesis and In Vitro Characterization of Glycopeptide Drug Candidates Related to PACAP(1–23)
por: Apostol, Christopher R., et al.
Publicado: (2021)

The role of opioid receptors in modulating Alzheimer’s Disease
por: Tanguturi, Parthasaradhireddy, et al.
Publicado: (2023)

The Delta-Specific Opioid Glycopeptide BBI-11008: CNS Penetration and Behavioral Analysis in a Preclinical Model of Levodopa-Induced Dyskinesia
por: Bartlett, Mitchell J., et al.
Publicado: (2020)

CNS active O-linked glycopeptides
por: Jones, Evan M., et al.
Publicado: (2015)

Discovery of PACAP and its receptors in the brain
por: Hirabayashi, Takahiro, et al.
Publicado: (2018)

Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists
por: Tanguturi, Parthasaradhireddy, et al.
Publicado: (2021)

Correction: Tanguturi et al. Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists. Molecules 2021, 26, 6693
por: Tanguturi, Parthasaradhireddy, et al.
Publicado: (2022)

Highly-selective µ-opioid receptor antagonism does not block L-DOPA-induced dyskinesia in a rodent model
por: Bartlett, Mitchell J., et al.
Publicado: (2020)

Colony-Stimulating Factor-1 Receptor Inhibition Transiently Attenuated the Peripheral Immune Response to Experimental Traumatic Brain Injury
por: Giordano, Katherine R., et al.
Publicado: (2023)

The Neuroprotective and Biomarker Potential of PACAP in Human Traumatic Brain Injury
por: Toth, Denes, et al.
Publicado: (2020)

The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease
por: Cherait, Asma, et al.
Publicado: (2023)

Protective Effects of PACAP in Peripheral Organs
por: Toth, Denes, et al.
Publicado: (2020)

Neurochemical changes in different brain regions induced by PACAP - relations to neuroprotection
por: Reglodi, Dora, et al.
Publicado: (2015)

Synthesis of glycopeptides and glycopeptide conjugates
por: Doelman, Ward, et al.
Publicado: (2022)

Stability Test of PACAP in Eye Drops
por: Kovacs, Anita K., et al.
Publicado: (2020)

Age-At-Injury Influences the Glial Response to Traumatic Brain Injury in the Cortex of Male Juvenile Rats
por: Green, Tabitha R. F., et al.
Publicado: (2022)

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma
por: Waschek, James A., et al.
Publicado: (2018)

PACAP Controls Endocrine and Behavioral Stress Responses via Separate Brain Circuits
por: Jiang, Sunny Zhihong, et al.
Publicado: (2023)

Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish
por: Nakamachi, Tomoya, et al.
Publicado: (2019)

Can Amphipathic Helices Influence the CNS Antinociceptive Activity of Glycopeptides Related to β-Endorphin?
por: Li, Yingxue, et al.
Publicado: (2014)

The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer’s Disease
por: Green, Tabitha R. F., et al.
Publicado: (2020)

Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides
Publicado: (1995)

Distribution of PACAP and PAC1 Receptor in the Human Eye
por: Patko, Evelin, et al.
Publicado: (2022)

Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals
por: Köves, Katalin, et al.
Publicado: (2020)

Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury
por: Broome, Sarah Thomas, et al.
Publicado: (2023)

The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy
por: Kvarik, Timea, et al.
Publicado: (2021)

PNA6, a Lactosyl Analogue of Angiotensin-(1-7), Reverses Pain Induced in Murine Models of Inflammation, Chemotherapy-Induced Peripheral Neuropathy, and Metastatic Bone Disease
por: Sulaiman, Maha I., et al.
Publicado: (2023)

Glycopeptide antibiotics /
Publicado: (1994)

Traumatic Brain Injury Characteristics Predictive of Subsequent Sleep-Wake Disturbances in Pediatric Patients
por: Gerald, Brittany, et al.
Publicado: (2022)

PACAP is Implicated in the Stress Axes
por: Hashimoto, Hitoshi, et al.
Publicado: (2011)

Protective effects of PACAP in ischemia
por: Reglodi, Dora, et al.
Publicado: (2018)

Multimodal Role of PACAP in Glioblastoma
por: D’Amico, Agata Grazia, et al.
Publicado: (2021)

Effect of PACAP on Heat Exposure
por: Suzuki, Keisuke, et al.
Publicado: (2023)

PACAP38/PAC1 Signaling Induces Bone Marrow-Derived Cells Homing to Ischemic Brain
por: Lin, Chen-Huan, et al.
Publicado: (2015)

Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors
por: Lu, Jessica, et al.
Publicado: (2022)

Antifreeze glycopeptide diastereomers
por: Nagel, Lilly, et al.
Publicado: (2012)

Developments in Glycopeptide Antibiotics
por: Blaskovich, Mark A. T., et al.
Publicado: (2018)

From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment
por: Tanaka, Masaru, et al.
Publicado: (2023)

gH625-liposomes deliver PACAP through a dynamic in vitro model of the blood–brain barrier
por: Barra, Teresa, et al.
Publicado: (2022)

Diffuse traumatic brain injury substantially alters plasma growth hormone in the juvenile rat
por: Ortiz, J Bryce, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ja66gjs4ibstln8b13r8vqmjp9