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Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2
[Image: see text] Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of a 1′-cyano-4-aza-7,9-dideazaadenosine C-nucleoside (GS-441524) that is FDA approved for the treatment of hospitalized patients with COVID-19. The prodrug, initially invented for respiratory syncyti...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887656/ https://www.ncbi.nlm.nih.gov/pubmed/35291757 http://dx.doi.org/10.1021/acsmedchemlett.1c00624 |