Directed invasion of cancer cell spheroids inside 3D collagen matrices oriented by microfluidic flow in experiment and simulation

Invasion is strongly influenced by the mechanical properties of the extracellular matrix. Here, we use microfluidics to align fibers of a collagen matrix and study the influence of fiber orientation on invasion from a cancer cell spheroid. The microfluidic setup allows for highly oriented collagen f...

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Detalles Bibliográficos
Autores principales: Geiger, Florian, Schnitzler, Lukas G., Brugger, Manuel S., Westerhausen, Christoph, Engelke, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887745/
https://www.ncbi.nlm.nih.gov/pubmed/35231060
http://dx.doi.org/10.1371/journal.pone.0264571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887745/
https://www.ncbi.nlm.nih.gov/pubmed/35231060
http://dx.doi.org/10.1371/journal.pone.0264571

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