Sphingosine 1-Phosphate-Upregulated COX-2/PGE(2) System Contributes to Human Cardiac Fibroblast Apoptosis: Involvement of MMP-9-Dependent Transactivation of EGFR Cascade

Human cardiac fibroblasts (HCFs) play key roles in normal physiological functions and pathological processes in the heart. Our recent study has found that, in HCFs, sphingosine 1-phosphate (S1P) can upregulate the expression of cyclooxygenase-2 (COX-2) leading to prostaglandin E(2) (PGE(2)) generati...

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Detalles Bibliográficos
Autores principales: Yang, Chien-Chung, Hsiao, Li-Der, Shih, Ya-Fang, Su, Mei-Hsiu, Yang, Chuen-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888119/
https://www.ncbi.nlm.nih.gov/pubmed/35242277
http://dx.doi.org/10.1155/2022/7664290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888119/
https://www.ncbi.nlm.nih.gov/pubmed/35242277
http://dx.doi.org/10.1155/2022/7664290

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