Equipping Coiled-Coil Peptide Dimers With Furan Warheads Reveals Novel Cross-Link Partners

Using a coiled-coil peptide dimer as a model system to explore furan reactivity, we describe novel cross-link partners of furan warheads for site-specific cross-linking. We demonstrate that replacement of weak interhelical ionic contacts with a furan moiety and its potential cross-link partner affor...

Descripción completa

Detalles Bibliográficos
Autores principales: Miret-Casals, Laia, Van De Putte, Sander, Aerssens, Dorien, Diharce, Julien, Bonnet, Pascal, Madder, Annemieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888431/
https://www.ncbi.nlm.nih.gov/pubmed/35252125
http://dx.doi.org/10.3389/fchem.2021.799706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888431/
https://www.ncbi.nlm.nih.gov/pubmed/35252125
http://dx.doi.org/10.3389/fchem.2021.799706

Ejemplares similares