Synthesis, crystal structure, DFT and molecular docking studies of N-acetyl-2,4-[diaryl-3-azabicyclo[3.3.1]nonan-9-yl]-9-spiro-4′-acetyl-2′-(acetylamino)-4′,9-dihydro-[1′,3′,4′]-thiadiazoles: A potential SARS-nCoV-2 Mpro (COVID-19) inhibitor

In this paper, we describe the synthesis and crystal structure analysis of N-acetyl-2,4-[diphenyl-3-azabicyclo[3.3.1]nonan-9-yl]-9-spiro-4′-acetyl-2′-(acetylamino)-4′,9-dihydro-[1′,3′,4′]-thiadiazole (3a) and N-acetyl- 2,4-[bis(p-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-yl]-9-spiro-4′-acetyl-2′-(ac...

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Detalles Bibliográficos
Autores principales: Rajamanickam, Ramachandran, Mannangatty, Rani, Sampathkumar, Jayanthi, Senthamaraikannan, Kabilan, Diravidamani, Barathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888462/
https://www.ncbi.nlm.nih.gov/pubmed/35250091
http://dx.doi.org/10.1016/j.molstruc.2022.132747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888462/
https://www.ncbi.nlm.nih.gov/pubmed/35250091
http://dx.doi.org/10.1016/j.molstruc.2022.132747

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