Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca(2+)-induced proteostasis disease stress

The cellular defense mechanisms against cumulative endo-lysosomal stress remain incompletely understood. Here, we identify Ubr1 as a protein quality control (QC) E3 ubiquitin-ligase that counteracts proteostasis stresses by facilitating endosomal cargo-selective autophagy for lysosomal degradation....

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Detalles Bibliográficos
Autores principales: Wang, Ben B., Xu, Haijin, Isenmann, Sandra, Huang, Cheng, Elorza-Vidal, Xabier, Rychkov, Grigori Y., Estévez, Raúl, Schittenhelm, Ralf B., Lukacs, Gergely L., Apaja, Pirjo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888484/
https://www.ncbi.nlm.nih.gov/pubmed/35233680
http://dx.doi.org/10.1007/s00018-022-04191-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888484/
https://www.ncbi.nlm.nih.gov/pubmed/35233680
http://dx.doi.org/10.1007/s00018-022-04191-8

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