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Transposase-CRISPR mediated targeted integration (TransCRISTI) in the human genome
Various methods have been used in targeted gene knock-in applications. CRISPR-based knock-in strategies based on homology-independent repair pathways such as CRISPR HITI have been shown to possess the best efficiency for gene knock-in in mammalian cells. However, these methods suffer from the probab...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888626/ https://www.ncbi.nlm.nih.gov/pubmed/35232993 http://dx.doi.org/10.1038/s41598-022-07158-8 |