Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor

The role of dimer formation for the onset of catalytic activity of SARS-CoV-2 main protease (MPro(WT)) was assessed using a predominantly monomeric mutant (MPro(M)). Rates of MPro(WT) and MPro(M) catalyzed hydrolyses display substrate saturation kinetics and second-order dependency on the protein co...

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Detalles Bibliográficos
Autores principales: Nashed, Nashaat T., Aniana, Annie, Ghirlando, Rodolfo, Chiliveri, Sai Chaitanya, Louis, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888643/
https://www.ncbi.nlm.nih.gov/pubmed/35233052
http://dx.doi.org/10.1038/s42003-022-03084-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888643/
https://www.ncbi.nlm.nih.gov/pubmed/35233052
http://dx.doi.org/10.1038/s42003-022-03084-7

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