Cargando…

Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor

The role of dimer formation for the onset of catalytic activity of SARS-CoV-2 main protease (MPro(WT)) was assessed using a predominantly monomeric mutant (MPro(M)). Rates of MPro(WT) and MPro(M) catalyzed hydrolyses display substrate saturation kinetics and second-order dependency on the protein co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nashed, Nashaat T., Aniana, Annie, Ghirlando, Rodolfo, Chiliveri, Sai Chaitanya, Louis, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888643/ https://www.ncbi.nlm.nih.gov/pubmed/35233052 http://dx.doi.org/10.1038/s42003-022-03084-7

Ejemplares similares

Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain
por: Nashed, Nashaat T., et al.
Publicado: (2022)

Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors
por: Aniana, Annie, et al.
Publicado: (2023)

Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor
por: Kovalevsky, Andrey, et al.
Publicado: (2022)

Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors
por: Kovalevsky, Andrey, et al.
Publicado: (2023)

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors
por: Silvestrini, Lucia, et al.
Publicado: (2021)

Transient lipid-bound states of spike protein heptad repeats provide insights into SARS-CoV-2 membrane fusion
por: Chiliveri, Sai Chaitanya, et al.
Publicado: (2021)

Quantifying the Monomer–Dimer Equilibrium of Tubulin with Mass Photometry
por: Fineberg, Adam, et al.
Publicado: (2020)

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
por: Gandhi, Amit K., et al.
Publicado: (2021)

Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging
por: Kasai, Rinshi S., et al.
Publicado: (2011)

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function
por: Ahmed, Zamal, et al.
Publicado: (2015)

Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles
por: Louis, John M., et al.
Publicado: (2016)

FGF9 monomer/dimer equilibrium regulates extracellular matrix affinity and tissue diffusion
por: Harada, Masayo, et al.
Publicado: (2009)

Corrigendum: Grb2 monomer–dimer equilibrium determines normal versus oncogenic function
por: Ahmed, Zamal, et al.
Publicado: (2015)

Solvent Dependence of the Monomer–Dimer Equilibrium of Ketone‐Substituted Triscatecholate Titanium(IV) Complexes
por: Kwamen, A. Carel N., et al.
Publicado: (2020)

Quantitative analysis of sterol-modulated monomer–dimer equilibrium of the β(1)-adrenergic receptor by DEER spectroscopy
por: Kubatova, Nina, et al.
Publicado: (2023)

Natural Polyphenols Inhibit the Dimerization of the SARS-CoV-2 Main Protease: The Case of Fortunellin and Its Structural Analogs
por: Panagiotopoulos, Athanasios A., et al.
Publicado: (2021)

Regulation of UVR8 photoreceptor dimer/monomer photo‐equilibrium in Arabidopsis plants grown under photoperiodic conditions
por: Findlay, Kirsten M.W., et al.
Publicado: (2016)

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2
por: Ferreira, Juliana C., et al.
Publicado: (2022)

The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium
por: Volbeda, Anne, et al.
Publicado: (2015)

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding
por: Martinez Fiesco, Juliana A., et al.
Publicado: (2022)

Dissecting Monomer-Dimer Equilibrium of an RNase P Protein Provides Insight Into the Synergistic Flexibility of 5’ Leader Pre-tRNA Recognition
por: Zeng, Danyun, et al.
Publicado: (2021)

The monomer-dimer algorithm and QCD at finite density
por: Karsch, Frithjof
Publicado: (1990)

Probing protein aggregation at buried interfaces: distinguishing between adsorbed protein monomers, dimers, and a monomer–dimer mixture in situ
por: Lu, Tieyi, et al.
Publicado: (2021)

Effect of pH on stability of dimer structure of the main protease of coronavirus-2
por: Boonamnaj, Panisak, et al.
Publicado: (2022)

Computational fragment screening of dimeric SARS-CoV-2 main protease
por: Reid, Rashad L., et al.
Publicado: (2023)

DRB4 dsRBD1 drives dsRNA recognition in Arabidopsis thaliana tasi/siRNA pathway
por: Chiliveri, Sai Chaitanya, et al.
Publicado: (2017)

Initiator protein dimerization plays a key role in replication control of Vibrio cholerae chromosome 2
por: Jha, Jyoti K., et al.
Publicado: (2014)

Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers
por: Maruyama, Ichiro N.
Publicado: (2014)

Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
por: Cheng, Shu-Chun, et al.
Publicado: (2010)

Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main Protease
por: Ho, Bo-Lin, et al.
Publicado: (2015)

Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease
por: Kaptan, Shreyas, et al.
Publicado: (2022)

Anionic polycondensation and equilibrium driven monomer formation of cyclic aliphatic carbonates
por: Hua, Geng, et al.
Publicado: (2018)

A Structural Comparison of SARS-CoV-2 Main Protease and Animal Coronaviral Main Protease Reveals Species-Specific Ligand Binding and Dimerization Mechanism
por: Ho, Chien-Yi, et al.
Publicado: (2022)

Thermally Activated Delayed Fluorescence from d(10)‐Metal Carbene Complexes through Intermolecular Charge Transfer and Multicolor Emission with a Monomer–Dimer Equilibrium
por: Cao, Lei, et al.
Publicado: (2020)

Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir
por: Paciaroni, Alessandro, et al.
Publicado: (2023)

Taking deterministic control of membrane protein monomer–dimer measurements
por: Fleming, Karen G.
Publicado: (2018)

The Reaction of Dimerization by Itself Reduces the Noise Intensity of the Protein Monomer
por: Liu, Feng-You, et al.
Publicado: (2019)

Interactome dynamics of RAF1-BRAF kinase monomers and dimers
por: Iglesias-Martinez, Luis F., et al.
Publicado: (2023)

Role of Monomer/Tetramer Equilibrium of Rod Visual Arrestin in the Interaction with Phosphorylated Rhodopsin
por: Imamoto, Yasushi, et al.
Publicado: (2023)

Handcuffing reversal is facilitated by proteases and replication initiator monomers
por: Bury, Katarzyna, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gun1oabe2qr7iipvrme9e48r4p