Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy

Mendelian Randomization (MR) studies are threatened by population stratification, batch effects, and horizontal pleiotropy. Although a variety of methods have been proposed to mitigate those problems, residual biases may still remain, leading to highly statistically significant false positives in la...

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Detalles Bibliográficos
Autores principales: Cinelli, Carlos, LaPierre, Nathan, Hill, Brian L., Sankararaman, Sriram, Eskin, Eleazar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888767/
https://www.ncbi.nlm.nih.gov/pubmed/35232963
http://dx.doi.org/10.1038/s41467-022-28553-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888767/
https://www.ncbi.nlm.nih.gov/pubmed/35232963
http://dx.doi.org/10.1038/s41467-022-28553-9

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