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The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
BACKGROUND: Advanced maternal age is associated with decreased oocyte quantity and quality as well as uterine and placental dysfunctions. These changes lead to infertility, pregnancy complications and birth defects in the offspring. As the mean age of giving birth is increasing worldwide, prevention...
Autores principales: | Secomandi, Laura, Borghesan, Michela, Velarde, Michael, Demaria, Marco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888999/ https://www.ncbi.nlm.nih.gov/pubmed/34918084 http://dx.doi.org/10.1093/humupd/dmab038 |
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