Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology

Matrin-3 (MATR3) is a DNA- and RNA-binding protein implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and distal myopathy. Here, we report the development of a yeast model of MATR3 proteotoxicity and aggregation. MATR3 is toxic and forms dynamic shell-like nuclear cond...

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Detalles Bibliográficos
Autores principales: Sprunger, Macy L., Lee, Ken, Sohn, Brian S., Jackrel, Meredith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889142/
https://www.ncbi.nlm.nih.gov/pubmed/35252808
http://dx.doi.org/10.1016/j.isci.2022.103900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889142/
https://www.ncbi.nlm.nih.gov/pubmed/35252808
http://dx.doi.org/10.1016/j.isci.2022.103900

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