Cargando…
Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology
Matrin-3 (MATR3) is a DNA- and RNA-binding protein implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and distal myopathy. Here, we report the development of a yeast model of MATR3 proteotoxicity and aggregation. MATR3 is toxic and forms dynamic shell-like nuclear cond...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889142/ https://www.ncbi.nlm.nih.gov/pubmed/35252808 http://dx.doi.org/10.1016/j.isci.2022.103900 |