Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study

BACKGROUND: This study aims to assess trends in patient-related factors and treatment strategies in Dutch colorectal cancer (CRC) patients and their effect on survival. METHODS: Data were obtained from the Rotterdam study, an ongoing population-based study of individuals aged ≥45 years. Between 1990...

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Autores principales: Lavrijssen, Birgit D. A., Ruiter, Rikje, Fest, Jesse, Ikram, Mohammad A., Stricker, Bruno H., van Eijck, Casper H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889566/
https://www.ncbi.nlm.nih.gov/pubmed/35252018
http://dx.doi.org/10.3389/fonc.2022.849951
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author Lavrijssen, Birgit D. A.
Ruiter, Rikje
Fest, Jesse
Ikram, Mohammad A.
Stricker, Bruno H.
van Eijck, Casper H. J.
author_facet Lavrijssen, Birgit D. A.
Ruiter, Rikje
Fest, Jesse
Ikram, Mohammad A.
Stricker, Bruno H.
van Eijck, Casper H. J.
author_sort Lavrijssen, Birgit D. A.
collection PubMed
description BACKGROUND: This study aims to assess trends in patient-related factors and treatment strategies in Dutch colorectal cancer (CRC) patients and their effect on survival. METHODS: Data were obtained from the Rotterdam study, an ongoing population-based study of individuals aged ≥45 years. Between 1990 and 2014, incident, pathology-confirmed CRC cases were divided into two groups based on date of diagnosis (either before or after January 1, 2003). Patient characteristics, initial treatment, and date of mortality were collected. Analyses were performed using Kaplan–Meier and Cox proportional hazard models. RESULTS: Of 14,928 individuals, 272 developed colon cancer and 124 rectal cancer. Median follow-up was 13.2 years. Patients diagnosed after January 1, 2003 were treated chemotherapeutically more often than those diagnosed prior to this date in colon cancer (28.6% vs. 9.1%, p = 0.02) and treated more often with chemotherapy (38.6% vs. 12.3%, p = 0.02) and radiotherapy (41.3% vs. 10.2%, p = 0.001) in rectal cancer. Overall survival, adjusted for patient, tumor characteristics, and treatment, improved in rectal cancer (HR, 0.31; 95% CI, 0.13–0.74) but remained stable in colon cancer (HR, 1.28; 95% CI, 0.84–1.95). CONCLUSION: Chemotherapeutic agents and radiotherapy are increasingly used in CRC patients. Survival in rectal cancer improved, whereas in colon cancer this was not observed.
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spelling pubmed-88895662022-03-03 Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study Lavrijssen, Birgit D. A. Ruiter, Rikje Fest, Jesse Ikram, Mohammad A. Stricker, Bruno H. van Eijck, Casper H. J. Front Oncol Oncology BACKGROUND: This study aims to assess trends in patient-related factors and treatment strategies in Dutch colorectal cancer (CRC) patients and their effect on survival. METHODS: Data were obtained from the Rotterdam study, an ongoing population-based study of individuals aged ≥45 years. Between 1990 and 2014, incident, pathology-confirmed CRC cases were divided into two groups based on date of diagnosis (either before or after January 1, 2003). Patient characteristics, initial treatment, and date of mortality were collected. Analyses were performed using Kaplan–Meier and Cox proportional hazard models. RESULTS: Of 14,928 individuals, 272 developed colon cancer and 124 rectal cancer. Median follow-up was 13.2 years. Patients diagnosed after January 1, 2003 were treated chemotherapeutically more often than those diagnosed prior to this date in colon cancer (28.6% vs. 9.1%, p = 0.02) and treated more often with chemotherapy (38.6% vs. 12.3%, p = 0.02) and radiotherapy (41.3% vs. 10.2%, p = 0.001) in rectal cancer. Overall survival, adjusted for patient, tumor characteristics, and treatment, improved in rectal cancer (HR, 0.31; 95% CI, 0.13–0.74) but remained stable in colon cancer (HR, 1.28; 95% CI, 0.84–1.95). CONCLUSION: Chemotherapeutic agents and radiotherapy are increasingly used in CRC patients. Survival in rectal cancer improved, whereas in colon cancer this was not observed. Frontiers Media S.A. 2022-02-16 /pmc/articles/PMC8889566/ /pubmed/35252018 http://dx.doi.org/10.3389/fonc.2022.849951 Text en Copyright © 2022 Lavrijssen, Ruiter, Fest, Ikram, Stricker and van Eijck https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lavrijssen, Birgit D. A.
Ruiter, Rikje
Fest, Jesse
Ikram, Mohammad A.
Stricker, Bruno H.
van Eijck, Casper H. J.
Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study
title Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study
title_full Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study
title_fullStr Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study
title_full_unstemmed Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study
title_short Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study
title_sort trends in staging, treatment, and survival in colorectal cancer between 1990 and 2014 in the rotterdam study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889566/
https://www.ncbi.nlm.nih.gov/pubmed/35252018
http://dx.doi.org/10.3389/fonc.2022.849951
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