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Flap Dynamics in Pepsin-Like Aspartic Proteases: A Computational Perspective Using Plasmepsin-II and BACE-1 as Model Systems

[Image: see text] The flexibility of β hairpin structure known as the flap plays a key role in catalytic activity and substrate intake in pepsin-like aspartic proteases. Most of these enzymes share structural and sequential similarity. In this study, we have used apo Plm-II and BACE-1 as model syste...

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Detalles Bibliográficos
Autores principales: Bhakat, Soumendranath, Söderhjelm, Pär
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889585/
https://www.ncbi.nlm.nih.gov/pubmed/35138093
http://dx.doi.org/10.1021/acs.jcim.1c00840