Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity

Infiltration of regulatory T cells (Tregs) in the tumor microenvironment suppresses anti-tumor immune response, and promotes tumor progression. Tumor necrosis factor receptor‐2 (TNFR2), which is highly expressed on Tregs, activates Tregs through nuclear factor kappa B (NF-κB) pathway. Moreover, TNFR...

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Detalles Bibliográficos
Autores principales: Chen, Yonglin, Jia, Manxue, Wang, Sharon, Xu, Sherry, He, Nanhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889907/
https://www.ncbi.nlm.nih.gov/pubmed/35251028
http://dx.doi.org/10.3389/fimmu.2022.835690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889907/
https://www.ncbi.nlm.nih.gov/pubmed/35251028
http://dx.doi.org/10.3389/fimmu.2022.835690

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