Cargando…

Glypican-3: A Novel and Promising Target for the Treatment of Hepatocellular Carcinoma

Glypican-3 (GPC3) is a membrane-associated proteoglycan that is specifically up-regulated in hepatocellular carcinoma (HCC) although rarely or not expressed in normal liver tissues, making it a perfect diagnostic and treatment target for HCC. Several GPC3-based clinical trials are ongoing and recent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Xiufeng, Liu, Xun, Lei, Yanna, Wang, Gang, Liu, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889910/ https://www.ncbi.nlm.nih.gov/pubmed/35251989 http://dx.doi.org/10.3389/fonc.2022.824208

Ejemplares similares

Multiparametric MRI combined with clinical factors to predict glypican-3 expression of hepatocellular carcinoma
por: Liu, Peijun, et al.
Publicado: (2023)

Glypican-3: A New Target for Diagnosis and Treatment of Hepatocellular Carcinoma
por: Guo, Meng, et al.
Publicado: (2020)

Glypican 3-Targeted Therapy in Hepatocellular Carcinoma
por: Nishida, Takahiro, et al.
Publicado: (2019)

Radiomics nomogram for prediction of glypican-3 positive hepatocellular carcinoma based on hepatobiliary phase imaging
por: Zhang, Ning, et al.
Publicado: (2023)

The expression of Ki-67 and Glypican -3 in hepatocellular carcinoma was evaluated by comparing DWI and (18)F-FDG PET/CT
por: Wang, Xuedong, et al.
Publicado: (2023)

Next-Generation Cancer Immunotherapy Targeting Glypican-3
por: Shimizu, Yasuhiro, et al.
Publicado: (2019)

Diagnostic accuracy and prognostic significance of Glypican-3 in hepatocellular carcinoma: A systematic review and meta-analysis
por: Jiang, Donglei, et al.
Publicado: (2022)

Reduced tumor stiffness quantified by tomoelastography as a predicative marker for glypican-3-positive hepatocellular carcinoma
por: Wang, Yihuan, et al.
Publicado: (2022)

IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma
por: Xu, Junnv, et al.
Publicado: (2021)

Identification of a Glypican-3 Binding Peptide From a Phage-Displayed Peptide Library for PET Imaging of Hepatocellular Carcinoma
por: Yan, Jiayao, et al.
Publicado: (2021)

Frequently expressed glypican‐3 as a promising novel therapeutic target for osteosarcomas
por: Nie, Jun‐Hua, et al.
Publicado: (2022)

Glypican-3-Targeted Alpha Particle Therapy for Hepatocellular Carcinoma
por: Bell, Meghan M., et al.
Publicado: (2020)

Diagnostic Value of Glypican-3 for Hepatocellular Carcinomas
por: El-Saadany, Sherif, et al.
Publicado: (2018)

The Role of TIM-3 in Hepatocellular Carcinoma: A Promising Target for Immunotherapy?
por: Ganjalikhani Hakemi, Mazdak, et al.
Publicado: (2020)

Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma
por: Zhang, Yi-Fan, et al.
Publicado: (2016)

A nomogram based on LI-RADS features, clinical indicators and quantitative contrast-enhanced MRI parameters for predicting glypican-3 expression in hepatocellular carcinoma
por: Song, Yan, et al.
Publicado: (2023)

Glypican-3: A molecular marker for the detection and treatment of hepatocellular carcinoma(☆)
por: Shih, Tsung-Chieh, et al.
Publicado: (2020)

Prognostic significance of glypican-3 in hepatocellular carcinoma: a meta-analysis
por: Xiao, Wei-Kai, et al.
Publicado: (2014)

Progress and Challenges of Predictive Biomarkers for Immune Checkpoint Blockade
por: Lei, Yanna, et al.
Publicado: (2021)

Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma
por: Sun, Luan, et al.
Publicado: (2021)

Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma
por: Kaseb, Ahmed Omar, et al.
Publicado: (2016)

Experimental Validation of Novel Glypican 3 Exosomes for the Detection of Hepatocellular Carcinoma in Liver Cirrhosis
por: Aydin, Yucel, et al.
Publicado: (2021)

Novel Nanotechnology Approaches to Overcome Drug Resistance in the Treatment of Hepatocellular Carcinoma: Glypican 3 as a Useful Target for Innovative Therapies
por: Mossenta, Monica, et al.
Publicado: (2022)

Prognostic significance of glypican-3 expression in hepatocellular carcinoma: A meta-analysis
por: Liu, Hong, et al.
Publicado: (2018)

The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer
por: Kolluri, Aarti, et al.
Publicado: (2019)

Neuroendocrine Tumors Show Altered Expression of Chondroitin Sulfate, Glypican 1, Glypican 5, and Syndecan 2 Depending on Their Differentiation Grade
por: García-Suárez, Olivia, et al.
Publicado: (2014)

Significance of Glypican-3 (GPC3) Expression in Hepatocellular Cancer Diagnosis
por: Sun, Bin, et al.
Publicado: (2017)

32A9, a novel human antibody for designing an immunotoxin and CAR-T cells against glypican-3 in hepatocellular carcinoma
por: Liu, Xiaoyu, et al.
Publicado: (2020)

Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector
por: Liu, Quan, et al.
Publicado: (2017)

Clinical Utility of Plasma Glypican-3 and Osteopontin as Biomarkers of Hepatocellular Carcinoma
por: Lee, Hyun Jung, et al.
Publicado: (2014)

A glypican-3-derived peptide vaccine against hepatocellular carcinoma
por: Sawada, Yu, et al.
Publicado: (2012)

Association between microRNA-527 and glypican-3 in hepatocellular carcinoma
por: Nomura, Kei, et al.
Publicado: (2021)

A Distinct Clinicopathological Feature and Prognosis of Young Gastric Cancer Patients Aged ≤ 45 Years Old
por: Huang, Qian, et al.
Publicado: (2021)

Experimental Validation of Novel Glypican 3 Exosomes for the Detection of Hepatocellular Carcinoma in Liver Cirrhosis [Corrigendum]
Publicado: (2022)

The Expression, Regulation, and Biomarker Potential of Glypican-1 in Cancer
por: Wang, Sen, et al.
Publicado: (2019)

Dysplastic Nodules with Glypican-3 Positive Immunostaining: A Risk for Early Hepatocellular Carcinoma
por: Gong, Li, et al.
Publicado: (2014)

Immunological efficacy of glypican-3 peptide vaccine in patients with advanced hepatocellular carcinoma
por: Tsuchiya, Nobuhiro, et al.
Publicado: (2017)

Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican-3 in hepatocellular carcinomas
por: Yorita, Kenji, et al.
Publicado: (2019)

Impaired Autophagy Response in Hepatocellular Carcinomas Enriches Glypican-3 in Exosomes, Not in the Microvesicles
por: Koksal, Ali Riza, et al.
Publicado: (2022)

Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer
por: Fleming, Bryan D., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_a2n4es53v3uq5a90me9s5e8c7i