CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages

Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore, the role of CFTR in maintaining the acidificatio...

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Detalles Bibliográficos
Autores principales: Badr, Asmaa, Eltobgy, Mostafa, Krause, Kathrin, Hamilton, Kaitlin, Estfanous, Shady, Daily, Kylene P., Abu Khweek, Arwa, Hegazi, Ahmad, Anne, Midhun N. K., Carafice, Cierra, Robledo-Avila, Frank, Saqr, Youssra, Zhang, Xiaoli, Bonfield, Tracey L., Gavrilin, Mikhail A., Partida-Sanchez, Santiago, Seveau, Stephanie, Cormet-Boyaka, Estelle, Amer, Amal O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890004/
https://www.ncbi.nlm.nih.gov/pubmed/35252032
http://dx.doi.org/10.3389/fcimb.2022.819554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890004/
https://www.ncbi.nlm.nih.gov/pubmed/35252032
http://dx.doi.org/10.3389/fcimb.2022.819554

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