Cargando…

CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages

Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore, the role of CFTR in maintaining the acidificatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Badr, Asmaa, Eltobgy, Mostafa, Krause, Kathrin, Hamilton, Kaitlin, Estfanous, Shady, Daily, Kylene P., Abu Khweek, Arwa, Hegazi, Ahmad, Anne, Midhun N. K., Carafice, Cierra, Robledo-Avila, Frank, Saqr, Youssra, Zhang, Xiaoli, Bonfield, Tracey L., Gavrilin, Mikhail A., Partida-Sanchez, Santiago, Seveau, Stephanie, Cormet-Boyaka, Estelle, Amer, Amal O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890004/ https://www.ncbi.nlm.nih.gov/pubmed/35252032 http://dx.doi.org/10.3389/fcimb.2022.819554

Ejemplares similares

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation
por: Estfanous, Shady, et al.
Publicado: (2021)

Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo
por: Estfanous, Shady, et al.
Publicado: (2021)

Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo
por: Estfanous, Shady, et al.
Publicado: (2021)

Caspase‐11 counteracts mitochondrial ROS‐mediated clearance of Staphylococcus aureus in macrophages
por: Krause, Kathrin, et al.
Publicado: (2019)

Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation
por: Caution, Kyle, et al.
Publicado: (2019)

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis
por: Eltobgy, Mostafa M., et al.
Publicado: (2022)

Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas
por: Jennewein, Lukas, et al.
Publicado: (2016)

MiR-101 and miR-144 Regulate the Expression of the CFTR Chloride Channel in the Lung
por: Hassan, Fatemat, et al.
Publicado: (2012)

Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice
por: Wellmerling, Jack H., et al.
Publicado: (2019)

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer’s disease The Ohio State University College of Medicine
por: Daily, Kylene P., et al.
Publicado: (2023)

Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels
por: Hassan, Fatemat, et al.
Publicado: (2014)

Membrane Lipids and CFTR: The Yin/Yang of Efficient Ceramide Metabolism
por: Bonfield, Tracey L.
Publicado: (2020)

A Novel Supplementation Approach to Enhance Host Response to Sublingual Vaccination
por: Rowe, John C., et al.
Publicado: (2019)

Optimization of Normal Human Bronchial Epithelial (NHBE) Cell 3D Cultures for in vitro Lung Model Studies
por: Rayner, Rachael E., et al.
Publicado: (2019)

CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection
por: Krause, Kathrin, et al.
Publicado: (2018)

Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma
por: Abu Khweek, Arwa, et al.
Publicado: (2020)

Differential gene expression of 3D primary human airway cultures exposed to cigarette smoke and electronic nicotine delivery system (ENDS) preparations
por: Rayner, Rachael E., et al.
Publicado: (2022)

Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes
por: Kim, Eunsoo, et al.
Publicado: (2022)

Addressing medical needs of adolescents and adults with autism spectrum disorders in a primary care setting
por: Saqr, Youssra, et al.
Publicado: (2017)

Routes of Allergic Sensitization and Myeloid Cell IKKβ Differentially Regulate Antibody Responses and Allergic Airway Inflammation in Male and Female Mice
por: Bonnegarde-Bernard, Astrid, et al.
Publicado: (2014)

Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization
por: Jee, Junbae, et al.
Publicado: (2015)

CFTR mutations altering CFTR fragmentation
por: Tosoni, Kendra, et al.
Publicado: (2012)

Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells
por: Phelps, Christopher C., et al.
Publicado: (2018)

Human Placental Trophoblasts Infected by Listeria monocytogenes Undergo a Pro-Inflammatory Switch Associated With Poor Pregnancy Outcomes
por: Johnson, Lauren J., et al.
Publicado: (2021)

IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites
por: Bonnegarde-Bernard, Astrid, et al.
Publicado: (2013)

Intestinal Epithelial Cells Regulate Gut Eotaxin Responses and Severity of Allergy
por: Kim, Eunsoo, et al.
Publicado: (2018)

Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease
por: Reynolds, Susan D., et al.
Publicado: (2022)

Pharmacological Responses of the G542X-CFTR to CFTR Modulators
por: Fang, Xinxiu, et al.
Publicado: (2022)

The Impact of Secondhand Smoke Exposure on Children with Cystic Fibrosis: A Review
por: Kopp, Benjamin T., et al.
Publicado: (2016)

CFTR Gating I: Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR)
por: Bompadre, Silvia G., et al.
Publicado: (2005)

Structural models of CFTR–AMPK and CFTR–PKA interactions: R-domain flexibility is a key factor in CFTR regulation
por: Siwiak, Marian, et al.
Publicado: (2011)

Acidification research : evaluation and policy applications
Publicado: (1992)

Development of CFTR Structure
por: Patrick, Anna E., et al.
Publicado: (2012)

CFTR gets together
por: Sedwick, Caitlin
Publicado: (2019)

Is CFTR an exchanger?: Regulation of HCO(3)(−)Transport and extracellular pH by CFTR
por: Massey, Marija K., et al.
Publicado: (2020)

Finite-Time Thermodynamic Modeling and Analysis of Seawater Acidification Process in Electrochemical Acidification Cell
por: Wang, Chao, et al.
Publicado: (2022)

Model of influenza virus acidification
por: Akole, Ajit, et al.
Publicado: (2019)

Ocean Acidification and Human Health
por: Falkenberg, Laura J., et al.
Publicado: (2020)

Characterization of Nasal Potential Difference in cftr Knockout and F508del-CFTR Mice
por: Saussereau, Emilie Lyne, et al.
Publicado: (2013)

Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors
por: Saint-Criq, Vinciane, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uhnubcbpso6dl5rpolqcbn6avf