Cargando…

A novel tyrosine hyperoxidation enables selective peptide cleavage

A novel tyrosine hyperoxidation enabling selective peptide cleavage is reported. The scission of the N-terminal amide bond of tyrosine was achieved with Dess–Martin periodinane under mild conditions, generating a C-terminal peptide fragment bearing the unprecedented hyperoxidized tyrosine motif, 4,5...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Shengping, De Leon Rodriguez, Luis M., Li, Freda F., Huang, Renjie, Leung, Ivanhoe K. H., Harris, Paul W. R., Brimble, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890263/
https://www.ncbi.nlm.nih.gov/pubmed/35356671
http://dx.doi.org/10.1039/d1sc06216f