Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment

In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosi...

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Autores principales: Foggetti, Giorgia, Li, Chuan, Cai, Hongchen, Petrov, Dmitri A., Winslow, Monte M., Politi, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890383/
https://www.ncbi.nlm.nih.gov/pubmed/35252550
http://dx.doi.org/10.1080/23723556.2021.1994328
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author Foggetti, Giorgia
Li, Chuan
Cai, Hongchen
Petrov, Dmitri A.
Winslow, Monte M.
Politi, Katerina
author_facet Foggetti, Giorgia
Li, Chuan
Cai, Hongchen
Petrov, Dmitri A.
Winslow, Monte M.
Politi, Katerina
author_sort Foggetti, Giorgia
collection PubMed
description In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosine kinase inhibitors and reflect the mutational landscape and treatment outcomes in the human disease.
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spelling pubmed-88903832022-03-03 Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment Foggetti, Giorgia Li, Chuan Cai, Hongchen Petrov, Dmitri A. Winslow, Monte M. Politi, Katerina Mol Cell Oncol Author’s Views In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosine kinase inhibitors and reflect the mutational landscape and treatment outcomes in the human disease. Taylor & Francis 2022-01-14 /pmc/articles/PMC8890383/ /pubmed/35252550 http://dx.doi.org/10.1080/23723556.2021.1994328 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s Views
Foggetti, Giorgia
Li, Chuan
Cai, Hongchen
Petrov, Dmitri A.
Winslow, Monte M.
Politi, Katerina
Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment
title Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment
title_full Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment
title_fullStr Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment
title_full_unstemmed Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment
title_short Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment
title_sort tumor suppressor pathways shape egfr-driven lung tumor progression and response to treatment
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890383/
https://www.ncbi.nlm.nih.gov/pubmed/35252550
http://dx.doi.org/10.1080/23723556.2021.1994328
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