G3BP1 modulates SPOP to promote prostate tumorigenesis

Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3(SPOP)), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However, it is unclear how the ubiquitin ligase acti...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Chandrani, Zhou, Pengbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890399/
https://www.ncbi.nlm.nih.gov/pubmed/35252555
http://dx.doi.org/10.1080/23723556.2022.2030171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890399/
https://www.ncbi.nlm.nih.gov/pubmed/35252555
http://dx.doi.org/10.1080/23723556.2022.2030171

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