G3BP1 modulates SPOP to promote prostate tumorigenesis

Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3(SPOP)), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However, it is unclear how the ubiquitin ligase acti...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Chandrani, Zhou, Pengbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890399/
https://www.ncbi.nlm.nih.gov/pubmed/35252555
http://dx.doi.org/10.1080/23723556.2022.2030171
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author Mukhopadhyay, Chandrani
Zhou, Pengbo
author_facet Mukhopadhyay, Chandrani
Zhou, Pengbo
author_sort Mukhopadhyay, Chandrani
collection PubMed
description Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3(SPOP)), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However, it is unclear how the ubiquitin ligase activity of SPOP is controlled and how dysregulation of SPOP contributes to malignant transformation. Here, we identified GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) as an interactor and upstream regulator of CUL3(SPOP), and it functions as an inhibitor of CUL3(SPOP) ubiquitin ligase, suggesting a distinctive mode of CUL3(SPOP) inactivation that aggravates prostate cancer.
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spelling pubmed-88903992022-03-03 G3BP1 modulates SPOP to promote prostate tumorigenesis Mukhopadhyay, Chandrani Zhou, Pengbo Mol Cell Oncol Author’s View Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3(SPOP)), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However, it is unclear how the ubiquitin ligase activity of SPOP is controlled and how dysregulation of SPOP contributes to malignant transformation. Here, we identified GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) as an interactor and upstream regulator of CUL3(SPOP), and it functions as an inhibitor of CUL3(SPOP) ubiquitin ligase, suggesting a distinctive mode of CUL3(SPOP) inactivation that aggravates prostate cancer. Taylor & Francis 2022-02-15 /pmc/articles/PMC8890399/ /pubmed/35252555 http://dx.doi.org/10.1080/23723556.2022.2030171 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
Mukhopadhyay, Chandrani
Zhou, Pengbo
G3BP1 modulates SPOP to promote prostate tumorigenesis
title G3BP1 modulates SPOP to promote prostate tumorigenesis
title_full G3BP1 modulates SPOP to promote prostate tumorigenesis
title_fullStr G3BP1 modulates SPOP to promote prostate tumorigenesis
title_full_unstemmed G3BP1 modulates SPOP to promote prostate tumorigenesis
title_short G3BP1 modulates SPOP to promote prostate tumorigenesis
title_sort g3bp1 modulates spop to promote prostate tumorigenesis
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890399/
https://www.ncbi.nlm.nih.gov/pubmed/35252555
http://dx.doi.org/10.1080/23723556.2022.2030171
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