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G3BP1 modulates SPOP to promote prostate tumorigenesis
Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3(SPOP)), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However, it is unclear how the ubiquitin ligase acti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890399/ https://www.ncbi.nlm.nih.gov/pubmed/35252555 http://dx.doi.org/10.1080/23723556.2022.2030171 |