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Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect
Genetic defects in SLC26A3 (DRA), an intestinal Cl(−)/HCO(3)(−) exchanger, result in congenital chloride diarrhea (CLD), marked by lifelong acidic diarrhea and a high risk of inflammatory bowel disease. Slc26a3(−/−) mice serve as a model to understand the pathophysiology of CLD and search for treatm...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890434/ https://www.ncbi.nlm.nih.gov/pubmed/35230892 http://dx.doi.org/10.1080/19490976.2022.2041943 |