Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability

Topoisomerase 1 (Top1) removes transcription-associated helical stress to suppress G4-formation and its induced recombination at genomic loci containing guanine-run containing sequences. Interestingly, Top1 binds tightly to G4 structures, and its inhibition or depletion can cause elevated instabilit...

Descripción completa

Detalles Bibliográficos
Autores principales: Berroyer, Alexandra, Bacolla, Albino, Tainer, John A., Kim, Nayun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890623/
https://www.ncbi.nlm.nih.gov/pubmed/35291312
http://dx.doi.org/10.15698/mic2022.03.771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890623/
https://www.ncbi.nlm.nih.gov/pubmed/35291312
http://dx.doi.org/10.15698/mic2022.03.771

Ejemplares similares