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Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability

Topoisomerase 1 (Top1) removes transcription-associated helical stress to suppress G4-formation and its induced recombination at genomic loci containing guanine-run containing sequences. Interestingly, Top1 binds tightly to G4 structures, and its inhibition or depletion can cause elevated instabilit...

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Detalles Bibliográficos
Autores principales:	Berroyer, Alexandra, Bacolla, Albino, Tainer, John A., Kim, Nayun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shared Science Publishers OG 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890623/ https://www.ncbi.nlm.nih.gov/pubmed/35291312 http://dx.doi.org/10.15698/mic2022.03.771

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