Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis

Ten-eleven translocation (Tet) enzymes promote DNA demethylation by oxidizing 5-methylcytosine. They are expressed during development and are essential for mouse gastrulation. However, their postgastrulation functions are not well established. We find that global or endothelial-specific loss of all...

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Detalles Bibliográficos
Autores principales: Ma, Liyang, Tang, Qin, Gao, Xin, Lee, Joun, Lei, Run, Suzuki, Masako, Zheng, Deyou, Ito, Keisuke, Frenette, Paul S., Dawlaty, Meelad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890710/
https://www.ncbi.nlm.nih.gov/pubmed/35235365
http://dx.doi.org/10.1126/sciadv.abm3470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890710/
https://www.ncbi.nlm.nih.gov/pubmed/35235365
http://dx.doi.org/10.1126/sciadv.abm3470

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