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Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis

Ten-eleven translocation (Tet) enzymes promote DNA demethylation by oxidizing 5-methylcytosine. They are expressed during development and are essential for mouse gastrulation. However, their postgastrulation functions are not well established. We find that global or endothelial-specific loss of all...

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Detalles Bibliográficos
Autores principales:	Ma, Liyang, Tang, Qin, Gao, Xin, Lee, Joun, Lei, Run, Suzuki, Masako, Zheng, Deyou, Ito, Keisuke, Frenette, Paul S., Dawlaty, Meelad M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890710/ https://www.ncbi.nlm.nih.gov/pubmed/35235365 http://dx.doi.org/10.1126/sciadv.abm3470

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