A Progressive Loss of phosphoSer138-Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington’s Disease: Possible Sex-Dependent Signaling

The R6/2 transgenic mouse model of Huntington’s disease (HD) carries several copies of exon1 of the huntingtin gene that contains a highly pathogenic 120 CAG-repeat expansion. We used kinome analysis to screen for kinase activity patterns in neural tissues from wildtype (WT) and R6/2 mice at a pre-s...

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Detalles Bibliográficos
Autores principales: Baharani, Akanksha, Wei, Zelan, Roesler, William J., Mousseau, Darrell D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891113/
https://www.ncbi.nlm.nih.gov/pubmed/33108594
http://dx.doi.org/10.1007/s10571-020-00984-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891113/
https://www.ncbi.nlm.nih.gov/pubmed/33108594
http://dx.doi.org/10.1007/s10571-020-00984-2

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