Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease

β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the major described β-secretase to generate Aβ peptides in Alzheimer’s disease (AD). However, all therapeutic attempts to block BACE1 activity and to improve AD symptoms have so far failed. A potential candidate for alternative Aβ p...

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Detalles Bibliográficos
Autores principales: Marengo, Liana, Armbrust, Fred, Schoenherr, Caroline, Storck, Steffen E., Schmitt, Ulrich, Zampar, Silvia, Wirths, Oliver, Altmeppen, Hermann, Glatzel, Markus, Kaether, Christoph, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891209/
https://www.ncbi.nlm.nih.gov/pubmed/35235058
http://dx.doi.org/10.1007/s00018-022-04205-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891209/
https://www.ncbi.nlm.nih.gov/pubmed/35235058
http://dx.doi.org/10.1007/s00018-022-04205-5

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