Cargando…

Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease

β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the major described β-secretase to generate Aβ peptides in Alzheimer’s disease (AD). However, all therapeutic attempts to block BACE1 activity and to improve AD symptoms have so far failed. A potential candidate for alternative Aβ p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marengo, Liana, Armbrust, Fred, Schoenherr, Caroline, Storck, Steffen E., Schmitt, Ulrich, Zampar, Silvia, Wirths, Oliver, Altmeppen, Hermann, Glatzel, Markus, Kaether, Christoph, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891209/ https://www.ncbi.nlm.nih.gov/pubmed/35235058 http://dx.doi.org/10.1007/s00018-022-04205-5

Ejemplares similares

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
por: Schönherr, Caroline, et al.
Publicado: (2016)

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP
por: Becker-Pauly, Christoph, et al.
Publicado: (2017)

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
por: Broder, Claudia, et al.
Publicado: (2013)

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
por: Jefferson, Tamara, et al.
Publicado: (2012)

The putative pleiotropic functions of meprin β in gastric cancer
por: Siemsen, Wiebke, et al.
Publicado: (2023)

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier
por: Mazura, Alexander D., et al.
Publicado: (2022)

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R
por: Gellrich, Antonin, et al.
Publicado: (2021)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

Meprin β contributes to collagen deposition in lung fibrosis
por: Biasin, V., et al.
Publicado: (2017)

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis
por: Oneda, Beatrice, et al.
Publicado: (2008)

Evaluation of (¹¹¹)In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers
por: Jodal, Andreas, et al.
Publicado: (2015)

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
por: Linnert, Miriam, et al.
Publicado: (2021)

Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau
por: Zampar, Silvia, et al.
Publicado: (2021)

Distinct contributions of meprins to skin regeneration after injury – Meprin α a physiological processer of pro-collagen VII
por: Kruppa, Daniel, et al.
Publicado: (2021)

New links for meprin β within the protease web
por: Canbay, Vahap, et al.
Publicado: (2022)

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach
por: Tan, Kathrin, et al.
Publicado: (2020)

Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles
por: Lückstädt, Wiebke, et al.
Publicado: (2021)

The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion
por: Huguenin, Maya, et al.
Publicado: (2008)

Hypoxia Associated Proteolytic Processing of OS-9 by the Metalloproteinase Meprin β
por: Martin, Barry Lee, et al.
Publicado: (2016)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)
por: Hou, Shurong, et al.
Publicado: (2021)

Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
por: Bülck, Cynthia, et al.
Publicado: (2023)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)
por: Wang, Chao, et al.
Publicado: (2021)

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β
por: Tan, Kathrin, et al.
Publicado: (2023)

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro
por: Bedau, Tillmann, et al.
Publicado: (2017)

A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
por: Kaether, Christoph, et al.
Publicado: (2004)

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α(2)
por: Schütte, André, et al.
Publicado: (2010)

Origin and Diversification of Meprin Proteases
por: Marín, Ignacio
Publicado: (2015)

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
por: Lottaz, Daniel, et al.
Publicado: (2011)

Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases
por: Karmilin, Konstantin, et al.
Publicado: (2019)

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
por: Arnold, Philipp, et al.
Publicado: (2017)

Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models
por: Wirths, Oliver, et al.
Publicado: (2020)

Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β
por: Menon, Preeti Kumaran, et al.
Publicado: (2019)

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin
por: Breig, Osman, et al.
Publicado: (2016)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
por: Bader, Angelika Sabine, et al.
Publicado: (2023)

N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer’s disease
por: Zampar, S., et al.
Publicado: (2020)

N-truncated Aβ(4–x) peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models
por: Wirths, Oliver, et al.
Publicado: (2017)

Role of Meprins to Protect Ileal Mucosa of Crohn's Disease Patients from Colonization by Adherent-Invasive E. coli
por: Vazeille, Emilie, et al.
Publicado: (2011)

Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy
por: Gooding, Jessica, et al.
Publicado: (2019)

Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1
por: Kurth, Vanessa, et al.
Publicado: (2023)

Nanoparticulate flurbiprofen reduces amyloid-β(42) generation in an in vitro blood–brain barrier model
por: Meister, Sabrina, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_khlpbenoarr36e56649s43fas2